Bonolive® is a natural ingredient derived from olives supporting healthy bones.
This patent protected ingredient is a true innovation for natural bone support
and a valuable addition to any bone health regimen.
Bone health from olives
BONOLIVE® is a highly water-soluble olive leaf extract standardised for its oleuropein content, a powerful phytonutrient unique to the olive tree. Oleuropein has shown in various studies to promote bone formation by enhancing the number and activity of the bone building cells (osteoblasts).
- Clinically proven health effects
- Unique mode of action
- Low daily dose of 250mg
- Superior bioavailability
- Patent protected
- Water soluble
BONOLIVE® is innovative and can be seamlessly integrated into dietary supplements, medical nutrition and functional beverages supporting healthy bone metabolism.
Bone metabolism (or bone remodeling) is a lifelong process where mature bone tissue is removed from the skeleton by osteoclasts <br>(a process called bone resorption) and new bone tissue is formed by osteoblasts (a process called ossification or new bone formation). These processes also control the reshaping or replacement of bone following injuries like fractures but also micro-damage, which occurs during normal activity.
In the first year of life, almost 100% of the skeleton is replaced. In adults remodeling proceeds at about 10% per year. As long as the bone-forming activity (absorption) is greater than the bone- breakdown (resorption), adults are able to maintain healthy bones. Many living cells present in bone originate from the same “mother cell”. These bone stem cells differentiate into different cell types: Osteoblasts (bone building cells), but also adipocytes (fat cells) or other cell types. Due to stress, inflammation and ageing this differentiation shifts to the production of more fat cells and fewer osteoblasts resulting in more fragile and fatty bones.
Mode of action
How Bonolive® works by Dr. Sam Possemiers
One of the key components in BONOLIVE® is oleuropein, a powerful phytonutrient unique to the olive tree. At cellular level oleuropein promotes bone formation by inhibiting adipocyte differentiation, and enhancing differentiation into osteoblasts.
BONOLIVE® is a clinically proven bone health supplement. A randomized, double-blind, placebo-controlled study proved that BONOLIVE® has significant effects on stimulation of bone building cells (osteoblasts) and blood lipid profiles.
The figure illustrates the 32% increase in osteocalcin levels (μg/L) over 12 months, which was statistically significant and indicates an increase in osteoblast activity (bone formation). Also blood lipid markers improved. A significant treatment effect was observed for total cholesterol LDL-cholesterol and triglyceride levels. Finally, DEXA scans showed subjects taking BONOLIVE® displayed a protection of bone mineral density at the lumbar spine and a higher gain of bone mineral density at the femur neck compared to those taking placebo.
Furthermore, results of a pharmacokinetic study show the intake of BONOLIVE® leads to an excellent bioavailability of bioactive metabolites in the target population for use of BONOLIVE®.